The question of performing PGD analysis or not is often disputed. In general, every IVF program will result in a few embryos that have poorly formed or incomplete chromosomes. This is true even for young, healthy egg and sperm donors — although the younger the donor the more healthy the embryos are likely to be. So is is true that PGD is less important if the donors are both young and have a proven fertility history.

The Value of PGDThat said, about 80% of failed early-stage miscarriages and failed pregnancies can be attributed to problems with the embryos’ chromosomes, so PGD can significantly improve your success rate. It can also save a lot of money overall by reducing the number of repeat FET cycles needed to get pregnant.

As for reducing the number of embryos…. PGD reduces the number of final embryos by eliminating those that have chromosomal problems. In some cases IPs may have as many as half of their embryos discarded due to chromosomal problems — but the remaining embryos are healthier and more likely to result in pregnancy.

There is a risk that the PGD process itself may damage some embryos. This is quite a small risk with a practiced, Western IVF clinic. However becasue the risk is unavoidable, we often skip PGD if the Intended Parents get very few embryos from their IVF cycle. In such a situation it’s important not to put any of the embryos at (even a minor) risk.

In the case of PGD for Gender Selection… on average you can assume half of your embryos will be boys, and the other half girls. So if you limit yourself to boy embryos only, you will reduce the number of embryos for transfer by 50%. However it is also possible that more than half of the embryos are the “undesired” gender, and your final embryos will be reduced more dramatically. (So even if you prefer boys, it is always smart not to discard any embryos based on gender, because you may find that girls are your only option if you want a successful pregnancy.)


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